固定科研人员/Faculty

程通/Tong Cheng

发布时间:2015/7/20 浏览量:921

程通,副教授

电 话:+86-592-2184113

E-mail:tcheng@xmu.edu.cn

1999年,厦门大学生物学专业,学士学位

2006年,厦门大学动物学专业,博士学位

 

研究领域(Research Area

主要从事病毒分子生物学、反向疫苗学、人源化动物模型的研究工作,目前研究方向包括肠道病毒广谱中和表位与疫苗研究,水痘-带状疱疹病毒反向疫苗学与减毒作用机制研究,乙型肝炎病毒人源化动物模型研究。

近年发表论文(* 通讯作者):

[1]       Xu L, He D, Li Z, Yang L, Zheng J, Yu H, Zhao H, Ye X, Qian H, Wang W, Liu J, Que Y, Shih JW, Zhang J, Zhu H, Cheng T*, Xia N*. A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71. Scientific Reports. 2015  [Epub ahead of print]

[2]       Liu J, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, Zhu H, Cheng T*, Xia N. A monoclonal antibody-based VZV Glycoprotein E Quantitative Assay and Its Application on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol, 2015, 99(11):4845-4853

[3]       Hou W, Yang L, Li S, Yu H, Xu L, He D, Chen M, He S, Ye X, Que Y, Shih JW, Cheng T*, Xia N*. Construction and characterization of an infectious cDNA clone of Echovirus 25. Virus Res. 2015, 205:41-44

[4]       Hou W, Yang L, He D, Zheng J, Xu L, Liu J, Liu Y, Zhao H, Ye X, Cheng T*, Xia N. Development of a coxsackievirus A16 neutralization test based on the enzyme-linked immunospot assay. J Virol Methods. 2015, 215-216:56-60

[5]       Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T*, Xia N. Protection against lethal Enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics. 2014, 4(5):498-513. (cover paper)

[6]       Yang L, He D, Tang M, Li Z, Liu C, Xu L, Chen Y, Du H, Zhao Q, Zhang J, Cheng T*, Xia N. Development of an enzyme-linked immunosorbent spot assay to measure serum-neutralizing antibodies against coxsackievirus B3. Clin Vaccine Immunol. 2014, 21(3):312-20.

[7]       Li Z, Xu L, He D, Yang L, Liu C, Chen Y, Shih JW, Zhang J, Zhao Q, Cheng T*, Xia N*. In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model. PLoS One. 2014, 9(10):e109391.

[8]       Chen L, Liu J, Wang W, Ye J, Wen L, Zhao Q, Zhu H, Cheng T*, Xia N. Development of a Varicella-zoster virus neutralization assay using a glycoprotein K antibody enzyme-linked immunosorbent spot assay. J Virol Methods, 2014, 200C:10-14.  

[9]       Mao Q1, Cheng T1, Zhu F1, Li J, Wang Y, Li Y, Gao F, Yang L, Yao X, Shao J, Xia N, Liang Z, Wang J. The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and children. PLoS One. 2013, 8(11):e79599. co-1st

[10]    Wang W, Cheng T*, Ma K, Xia D, Wang Y, Liu J, Du H, Shih JW, Zhang J, Zhao Q, Xia N. Development of a novel baculovirus titration method using the Enzyme-linked immunosorbent spot (ELISPOT) assay. J Virol Methods. 2013, 188(1-2):114-20.

[11]    Zhang T1, Cheng T1, Wei L, Cai Y, Yeo AE, Han J, Yuan YA, Zhang J, Xia N. Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct. Virol J. 2012, 9(1):118. co-1st

[12]    Zhang YL, Cheng T*, Cai YJ, Yuan Q, Liu C, Zhang T, Xia DZ, Li RY, Yang LW, Wang YB, Yeo AE, Shih JW, Zhang J, Xia NS. RNA Interference inhibits hepatitis B virus of different genotypes in vitro and in vivo. BMC Microbiol. 2010, 10:214.

[13]    Cheng T, Xu CY, Wang YB, Chen M, Wu T, Zhang J, Xia NS. A rapid and efficient method to express target genes in mammalian cells by baculovirus. World J Gastroenterol. 2004, 10:1612-1618

[14]    Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM. Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proc Natl Acad Sci USA. 2015 Jun 15. pii: 201509392.

[15]    Selariu A, Cheng T, Tang Q, Silver B, Yang L, Liu C, Ye X, Markus A, Goldstein RS, Cruz Cosme RS, Lin Y, Wen L, Qian H, Han J, Dulal K, Huang Y, Li Y, Xia N, Zhu H. ORF7 of Varicella Zoster Virus is a Neurotropic Factor. J Virol. 2012 , 86(16):8614-24.

[16]    Zhang Z, Selariu A, Warden C, Huang G, Huang Y, Zaccheus O, Cheng T, Xia N, Zhu H. Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor. PLoS Pathog. 2010, 6(7):e1000971.

 

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