固定科研人员/Faculty

李少伟/Shaowei Li

发布时间:2015/7/22 浏览量:1029

李少伟,博士  Li Shaowei, Ph.D. 教授,博士生导师 Professor

研究领域:结构疫苗学 (Structural Vaccinology)

电  话:+86-592-2880620

传  真:+86-592-2181258

E-mail:shaowei@xmu.edu.cn

 

 

简历 (Education and Work experience)

1998年,厦门大学生物化学专业,学士学位;

2003年,厦门大学生化与分子生物学/动物学专业,博士学位;

2003年,厦门大学生命科学学院讲师;

2006年,厦门大学生命科学学院副教授;

2011年,厦门大学生命科学学院/公共卫生学院教授、博士生导师。

B.S.  Biochemistry, Xiamen University, 1998

Ph.D. Biochemistry&Molecular Biology/Zoology, Xiamen University, 2003

Lecturer, School of Life Sciences, Xiamen University, 2003

Associate Professor, School of Life Sciences, Xiamen University, 2006

Professor, School of Life Sciences/School of Public Health, Xiamen University, 2011

 

研究领域 (Research Area)

  • 基因工程疫苗研究与开发

  • 重要传染病病毒免疫表位的结构和功能研究

  • 基于结构的分子模拟和分子设计

  • Research and development of recombinant human vaccine

  • Structural basis and functional implication for underlying immune epitopes of key infectious viruses

  • Structure-based molecular simulation and rational design for vaccine

 

代表性论文 (Selected Publications)(* Corresponding author)

1.      Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J, Ng MH, Hew CL, Li S*, Xia N*, Sivaraman J*.Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody. Cell Res. 2015 May;25(5): 604-20.

2.      Li S, Zhang J, Xia N*. Lessons from hepatitis E vaccine design. Curr Opin Virol. 2015 Apr;11:130-136.

3.      Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, Xin L, Wei M, Kong Z, Yu H, Gu Y, Zhang J, Li S*, Xia N*. Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody. PLoS One. 2015 Apr 23;10(4):e0123944.

4.      Li SW, Zhao Q, Wu T*, Chen S, Zhang J, Xia NS. The development of a recombinant hepatitis E vaccine HEV 239. Hum Vaccin Immunother. 2015;11(4):908-14.

5.      Gu Y, Cao F, Wang L, Hou W, Zhang J, Hew CL, Li S*, Yuan YA*, Xia N*. Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr 19;8(4):e61314.

6.      Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, Zhang J, Li S*, Xia N*.Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts. Protein Sci. 2013 Mar;22(3):314-26.

7.      Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL, Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10266-71.Epub 2011 Jun 3.

8.      Yu H, Li S*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model. 2011 May;17(5):987-95. Epub 2010 Jul 14.

9.      Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction. PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7.

10.  Yang K, Li S*, He F, Zhang J, Wei M, Pan H, Yang C, Xiong J, Zhang J, Xia N. Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutant from Saccharomyces Cerevisiae. J Biosci Bioeng. 2009 Jul;108(1):5-10.

11.  Yan Y, Li S*, Yang C, Luo W, Wang M, Chen Y, Luo H, Wu T, Zhang J,  Xia N. Prediction of a common neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking. Chinese Science Bulletin. 2008.53(1).

12.  Li S, Zhang J, Li Y, Ou S, Huang G, He Z, Ge S, Xian Y, Pang S, Ng M, Xia N*. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine. 2005 Apr 22;23(22):2893-2901.

13.   Li S, Zhang J, He Z, Gu Y, Liu R, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid. J Biol Chem. 2005 Feb 4;280(5):3400-6. Epub 2004 Nov 22.

 

荣誉、奖励及参加学术团体的情况 (Honors and award)

2011年入选教育部新世纪优秀人才,2011年福建省杰出青年基金、2010年厦门市杰出青年基金;主持国家自然科学基金、“863”重点项目子课题、新药创制重大专项及滚动项目等课题;获得国家科技进步二等奖、国家技术发明二等奖、中国高校科技进步一等奖等;发表SCI论文40余篇,申请国家发明专利24项,国际发明专利12项,获得授权7项;为主研制出戊肝疫苗、宫颈癌疫苗、艾滋诊断试剂等新药。

  • WIPO-SIPO Award for Chinese Outstanding Patented Invention (2012)

  • State Technological Invention Award (2010)

  • State Scientific and Technological Progress Award (2001)

 

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