固定科研人员/Faculty

陈毅歆/Yixi Chen

发布时间:2015/7/22 浏览量:893

陈毅歆,Chen YixinPh.D.  副教授

电话:+86-592-2880622

E-mail: yxchen2008@xmu.edu.cn

简历:

1999,福州大学 生工系,学士

2005,厦门大学 生命科学学院,硕士

2008,厦门大学 生命科学学院,博士

2009,厦门大学 生命科学学院,公共卫生学院,助理教授

2014,厦门大学 生命科学学院,公共卫生学院,副教授

1999, B.Sc., Dept. of Biological Engineering, Fuzhou University

2005, M.Sc., School of Life Sciences, Xiamen University

2008, Ph.D., School of Life Sciences, Xiamen University

2009, Assistant Professor, School of Life Sciences, School of Public Health, Xiamen University

2014, Associate Professor, School of Life Sciences, School of Public Health, Xiamen University

 

研究领域(Research Area)

针对人类病毒性传染病的病原体开展分子病毒学与免疫学研究,主要涉及流感病毒、肠道病毒和Epstein-Barr病毒等病原体。重点研究病原体靶标蛋白的抗原性变异规律、表位特征及生物学功能等,为研制病原体的诊断试剂、治疗性抗体药物和疫苗提供支持,在广谱免疫策略和广谱治疗性抗体筛选方面有独到经验。

Our group is dedicated to study the molecular virology and immunology of human pathogens. Our primary studying subjects are influenza virus, enterovirus, and Epstein-Barr virus and our aims are to reveal the changing antigenicity of target viral proteins; their key epitopes and their biological functions. Our final goals are to develop diagnostic kit, therapeutic antibody, and vaccine against specific viruses.  We have maintained a leading position in exploring strategies to elicit broad reactive antibodies. 

 

代表性论文 (Selected Publications) # Co-first author,* Corresponding author

(1)    Chen Y, Chan, KH, Kang Y, Chen H, Luk HK, Poon RW, Chan JF, Yuen KY, Xia N, Lau SK and Woo PC. A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus. Emerging Microbes & Infections,2015,4, e26. ( http://news.xmu.edu.cn/s/13/t/542/85/c7/info165319.htm )

(2)    Gui X, Li R, Zhang X, Shen C, Yu H, Guo X, Kang Y, Chen J, Chen H, Chen Y*, Xia N*. An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2. Virology,2014,464-465:11-20.

(3)    Gui X, Ge P, Wang X, Yang K, Yu H, Zhao Q, Chen Y*, Xia N*. Identification of a highly conserved and surface exposed B-cell epitope on the nucleoprotein of influenza A virus. Journal of Medical Virology,2014,86:995-1002.

(4)    Chen Y #, Li C #, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen P-J, Zhang J, Xia N. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity. Vaccine,2013,31:425-30.

(5)    Wu WL, Lau SY, Chen Y, Wang G, Mok BW, Wen X, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H. The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Research,2012,93:144-153.

(6)    Chen Y #, Zheng Q #, Yang K, Zen F, Lau S-Y, Wu WL, Huang S, Zhang J, Chen H, Xia N. Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination. Clinical Microbiology and Infection,2011,17:1347-1349.

(7)    Zheng Q, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H, Luo W, Xia N. Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy,2011,55:1349-1357.

(8)    Chen Y, Xu F, Gui X, Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AET, Zhang J, Guan Y, Chen H, Xia N. A rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009. Journal of Virological Methods, 2009,167:100-102.

(9)    Chen Y #, Qin K #, Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen H, and Xia N. Broad Cross-Protection against H5N1 Avian Influenza Virus Infection by Means of Monoclonal Antibodies that Map to Conserved Viral Epitopes. Journal of Infectious Diseases,2009,199:49-58.

(10)WL Wu #, Chen Y #, Wang P, Song W, Lau SY, Rayner JM, Smith GJD, Webster RG, Peiris JSM, Lin T, Xia N, Guan Y and Chen H. Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. Journal of Virology, 2008,82:1798-1807.

(11)Chen Y, F Xu, X Fan, H Luo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, and J Zhang. Evaluation of a rapid test for detection of H5N1 avian influenza virus. Journal of Virological Methods,2008,154:213-215.

 

授权发明专利 (Patents)

(1)    Chen Yixin, Luo Wenxin, Zhang Jun, Xia Ningshao, Guan Yi, Chen Honglin. Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof. United States Patent No. US8603467B2, Date of Patent: Dec.10, 2013 (美国发明专利)

(2)    陈毅歆,罗文新,张军,夏宁邵,管轶,陈鸿霖. H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合片段及其用途. 2013.2,中国发明,专利号ZL200810110869.6

 

获资助课题(Grants)

(1)     2014-2017,国家自然基金(面上项目),人肠道病毒71型构象性中和表位的确定及其诱导抗病毒免疫保护应答

(2)     2013-2016,Sanofi Pasteur Biologics,LLC., Sanofi Pasteur –Xiamen University NIDVD Collaborative Research Plan Identifying cross-neutralizing mAb’s to seasonal Influenza viruses

(3)     2012-2015,国家高技术研究发展计划(863计划),抗体产业化关键原材料研发及生产平台的建立

(4)     2011-2013,国家科技重大专项“新药创制”,H5N1禽流感病毒广谱治疗性单克隆抗体临床前研究

(5)     2012-2013,厦门市科技项目,H5N1禽流感病毒广谱治疗性单克隆抗体临床前研究

(6)     2011-2014,福建省科技重大专项,系列肿瘤相关免疫诊断试剂高活性的关键原料的研制及产业化

 

(7)     2010-2012,国家自然基金(青年基金),H5N1禽流感病毒血凝素广谱中和表位的结构研究

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