固定科研人员/Faculty

李子婧/Zijing Li

发布时间:2015/7/22 浏览量:900

李子婧 博士 助理教授

2009年7月毕业于北京师范大学化学学院,取得化学专业学士学位。同年进入北京师范大学刘伯里院士课题组攻读博士学位,钻研开发放射性核素标记的用于阿尔茨海默病早期、准确、无创诊断的Aβ斑块显像剂。2012年获得国家留学基金委公派留学资格到纽约大学医学院Center for Biomedical Imaging作为联合培养博士生交流16个月。2014年7月毕业于北京师范大学并获得博士学位。

 

研究方向

现主要研究用于中枢神经系统PET/SPECT 显像的小分子放射性探针的设计、合成、标记以及体内外评价等工作。

通信地址:厦门市翔安区翔安南路厦门大学公共卫生学院曾宪梓楼138

邮编:361102

电话/传真:0592-2880646

电子邮箱: bnulzj@gmail.com

发表文章

[1] Zijing Li, Mengchao Cui, Jinming Zhang, Jiapei Dai, Xiaojun Zhang, Peng Chen, Hongmei Jia, Boli Liu. Novel 18F-labeled dibenzylideneacetone derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques. European Journal of Medicinal Chemistry, 84 (2014) 628 - 638.

[2] Zijing Li, Mengchao Cui, Jiapei Dai, Xuedan Wang, Pingrong Yu, Yanping Yang, Jianhua Jia, Hualong Fu, Masahiro Ono, Hongmei Jia, Hideo Saji, and Boli Liu. Novel Cyclopentadienyl Tricarbonyl Complexes of 99mTc Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain. Journal of Medicinal Chemistry, 56 (2013) 471 - 482.

[3] Yanping Yang, Mengchao Cui, Bing jin, Xuedan Wang, Zijing Li, Pingrong Yu, Jianhua Jia, Hualong Fu, Hongmei Jia, Boli Liu. 99mTc-labeled dibenzylideneacetone derivatives as potential SPECT probes for in vivo imaging of β-amyloid plaque. European Journal of Medicinal Chemistry, 64 (2013) 90 - 98.

[4] Hualong Fu; lihai Yu; Mengchao Cui; Jinming Zhang, Xiaojun Zhang, Zijing Li; Xuedan Wang; Jianhua Jia; Pingrong Yu; Hongmei Jia; Boli Liu. Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques. Bioorganic & Medicinal Chemistry, 21 (2013) 3708 - 3714.

[5] Mengchao Cui, Xuedan Wang, Pingrong Yu, Jinming Zhang, Zijing Li, Xiaojun Zhang, Yanping Yang, Masahiro Ono, Hongmei Jia, Hideo Saji, and Boli Liu, Synthesis and Evaluation of Novel 18F Labeled 2-Pyridinylbenzoxazole and 2-Pyridinylbenzothiazole Derivatives as Ligands for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques, Journal of Medicinal Chemistry, 55 (2012) 9283 - 9296.

[6] Pingrong Yu, Mengchao Cui, Xuedan Wang, Xiaojun Zhang, Zijing Li, Yanping Yang, Jianhua Jia, Jinming Zhang, Masahiro Ono, Hideo Saji, Hongmei Jia, Boli Liu, 18F-Labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques. European Journal of Medicinal Chemistry, 57 (2012) 51 - 58.

[7] Wang, Xuedan; Cui, Mengchao; Yu, Pingrong; Li, Zijing; Yang, Yanping; Jia, Hongmei; Liu, Boli. Synthesis and biological evaluation of novel technetium-99m labeled phenylbenzoxazole derivatives as potential imaging probes for β-amyloid plaques in brain. Bioorganic & Medicinal Chemistry Letters, 22 (2012) 4327 - 4331.

[8] Zi-Jing Li, Hui-Ying Ren, Meng-Chao Cui, Winnie Deuther-Conrad, Rui-Kun Tang, Jörg Steinbach, Peter Brust, Bo-Li Liu, Hong-Mei Jia, Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging, Bioorganic & Medcinal Chemistry, 19 (2011) 2911 - 2917.

[9] Mengchao Cui, Zijing Li, Ruikun Tang, Hongmei Jia, Boli Liu, Novel (E)-5-styryl-2,2'-bithiophene Derivatives as Ligands for β-amyloid Plaques, European Journal of Medicinal Chemistry, 46 (2011) 2908 - 2916.

[10] Mengchao Cui, Ruikun Tang, Zijing Li, Huiying Ren, Boli Liu, 99mTc- and Re-labeled 6-dialkylamino-2-naphthylethylidene derivatives as imaging probes for β-amyloid plaques, Bioorganic & Medicinal Chemistry Letters, 21 (2011) 1064 - 1068.

[11] Meng-Chao Cui, Zi-Jing Li, Rui-Kun Tang, Bo-Li Liu, Synthesis and evaluation of novel benzothiazole derivatives based on the bithiophene structure as potential radiotracers for β-amyloid plaques in Alzheimer’s disease, Bioorganic & Medcinal Chemistry, 18 (2010) 2777 - 2784.

[12] Wenge Wang, Xiumin Shen, Fengnian Ma, Zijing Li, Cong Zhang, Chiral amino alcohols derived from natural amino acids as chiral solvating agents for carboxylic acids, Tetrahedron: Asymmetry, 19 (2008) 1193 - 1199.

发明专利

一类与Aβ斑块具有高亲和力的新型小分子化合物及其合成和应用。发明人:崔孟超,刘伯里,李子婧。专利号:2009 1 0090109.8。

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